Experimental models of membranous nephropathy
JA Jefferson, JW Pippin, SJ Shankland - Drug Discovery Today: Disease …, 2010 - Elsevier
Membranous nephropathy (MN) is one of the commonest glomerular diseases, typically
presenting in older males with nephrotic syndrome. The development and characterization
of animal models of MN, in particular, the passive Heymann nephritis (PHN) model, has
greatly advanced our understanding of this disease. In this review we discuss the different
animal models of human MN that are available, with an emphasis on the PHN model,
including technical issues, the typical disease course and its application to human disease.
presenting in older males with nephrotic syndrome. The development and characterization
of animal models of MN, in particular, the passive Heymann nephritis (PHN) model, has
greatly advanced our understanding of this disease. In this review we discuss the different
animal models of human MN that are available, with an emphasis on the PHN model,
including technical issues, the typical disease course and its application to human disease.
